Purpose This study aimed to perform a systematic review and meta-analysis of randomized
trials investigating the effect of continuous positive airway pressure (CPAP) on non-invasive
markers of arterial stiffness in patients with OSA. Methods The purpose of the study was to
evaluate the effect of CPAP on markers of arterial stiffness (pulse wave velocity (PWV) and
augmentation index (Aix)) in patients with OSA. The study adhered to Preferred Reporting
Items for Systematic Reviews and Meta-Analyses guidelines. We systematically reviewed …

Introduction: Obstructive sleep apnea (OSA) is a major cause of hypertension, which is
tightly associated with arterial stiffness, a marker of target organ damage and cardiovascular
risk. Although continuous positive airway pressure (CPAP) is considered an effective
treatment for OSA, its impact on arterial stiffness is controversial. Hypothesis: CPAP has a
positive effect on arterial stifness in patients with OSA. Methods: We systematically searched
databases for randomized clinical trials (RCT) evaluating the changes in arterial stiffness …